Certification of Pharmacy Technicians (ExCPT) Practice Exam

Which of the following drugs is not an antidepressant?

1. Citalopram

2. Trazodone

3. Venlafaxine

4. Diazepam

The correct answer is: Diazepam

Diazepam is not classified as an antidepressant; rather, it is a benzodiazepine that is primarily used for its anxiolytic (anti-anxiety), sedative, muscle relaxant, and anticonvulsant properties. It works by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain, which has a calming effect. In contrast, the other medications listed—Citalopram, Trazodone, and Venlafaxine—are all considered antidepressants. Citalopram is a selective serotonin reuptake inhibitor (SSRI) often prescribed to treat depression and anxiety. Trazodone, while sometimes used as a sleep aid, is primarily used to treat major depressive disorder and works by inhibiting serotonin reuptake. Venlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) that is also effective in treating major depressive disorder as well as anxiety disorders. Recognizing these classifications helps in understanding the therapeutic uses and mechanisms of action of various medications in the context of mental health treatment.