Certification of Pharmacy Technicians (ExCPT) Practice Exam

How should Premarin cream be administered?

1. Vaginally

2. Rectally

3. On the stomach

4. On the forearms

The correct answer is: Vaginally

Premarin cream, a medication primarily used for hormone replacement therapy, is specifically formulated for vaginal administration. This route allows for direct application to the vaginal mucosa, which helps in effectively treating symptoms associated with estrogen deficiency, such as vaginal dryness and atrophy. By administering the cream vaginally, it can achieve higher local concentrations at the site of action, maximizing therapeutic benefits and minimizing systemic exposure compared to other routes. The other options provided are not appropriate for the administration of Premarin cream. Using it rectally would not target the intended area for its effects, applying it on the stomach or forearms would not provide the necessary absorption needed for vaginal treatment and does not correspond to its intended use. Therefore, the correct administration of Premarin cream is indeed vaginally.